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LaSSO Research Group

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Laboratory for Spatial and Systems Oncology

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The Hwang Laboratory (or LaSSO Research Group) has a deep interest in the immense phenotypic, temporal and spatial heterogeneity of tumor ecosystems and the many insights that can only be gleaned by studying these systems at the level of their individual components—single molecules or cells. Research in the Hwang Laboratory is focused on studying tumor-stroma interactions at unprecedented resolution through the development and application of techniques in single-cell and spatial biology, multiplexed imaging, and functional genetic screens to patient-derived specimens, organoids, and mouse models to elucidate mechanisms of:

  1. Therapeutic resistance mediated by genetic, epigenetic, and phenotypic factors including cell state plasticity

  2. Treatment-mediated remodeling of the spatial microarchitecture of tumors and underlying cancer cell-stromal interactions

  3. Tumor-nerve crosstalk, which plays a critical role in the pathophysiology and morbidity of many malignancies but remains understudied. 

Feel free to check out two of our most recent podcasts regarding our work!

  1. https://www.mendelspod.com/p/will-hwang-of-mass-general-on-discovery-859

  2. https://rss.com/podcasts/spatial-navigator/669912/

Dr. Hwang was also interviewed in GEN magazine! Check it out here:

  1. https://www.genengnews.com/sponsored/multiomics-in-pancreatic-cancer-a-conversation-with-dr-william-hwang/

The Hwang Lab was also awarded the People's Choice Award at the MIT Koch Institute Image Awards Ceremony. You can watch the video of Dr. Hwang's talk at the ceremony reception below!

RESEARCH INTERESTS

Click on each project to explore what our team is working on

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MILESTONES

Timeline of past events, awards, and honors

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