LaSSO Research Group
Laboratory for Spatial and Systems Oncology
The Hwang Laboratory (or LaSSO Research Group) has a deep interest in the immense phenotypic, temporal and spatial heterogeneity of tumor ecosystems and the many insights that can only be gleaned by studying these systems at the level of their individual components—single molecules or cells. Research in the Hwang Laboratory is focused on studying tumor-stroma interactions at unprecedented resolution through the development and application of techniques in single-cell and spatial biology, multiplexed imaging, and functional genetic screens to patient-derived specimens, organoids, and mouse models to elucidate mechanisms of:
Therapeutic resistance mediated by genetic, epigenetic, and phenotypic factors including cell state plasticity
Treatment-mediated remodeling of the spatial microarchitecture of tumors and underlying cancer cell-stromal interactions
Tumor-nerve crosstalk, which plays a critical role in the pathophysiology and morbidity of many malignancies but remains understudied.
Feel free to check out two of our most recent podcasts regarding our work!
The Hwang Lab was also awarded the People's Choice Award at the MIT Koch Institute Image Awards Ceremony. You can watch the video of Dr. Hwang's talk at the ceremony reception below!
Timeline of past events, awards, and honors