William Hwang Lab
DIVERSITY STATEMENT
The Hwang Lab strongly believes that the most effective team is one composed of diverse backgrounds, skills, interests and perspectives. We are therefore committed to fostering a diverse scientific community and welcome all individuals irrespective of gender, race/ethnicity, sexual orientation, religion, cultural background, socioeconomic status, or physical ability. We are dedicated to understanding and challenging our own unconscious biases, as well as educating ourselves regarding the challenges that others may face in order to nurture an inclusive workplace that is welcoming for all.
AVAILABLE POSITIONS
We are currently looking for highly motivated postdoctoral research fellows, medical residents, graduate students, medical students, research technicians, associate computational biologists, and undergraduates to join our team!
For postdoctoral research fellows and research technicians, please click below to learn more about specific job descriptions/responsibilities and how to apply. For other positions, please directly reach out to Dr. Hwang (whwang1@mgh.harvard.edu).
Associate Computational Biologist Job Description
Description:
The Hwang Lab (Laboratory for Spatial and Systems Oncology) in the Center for Systems Biology, Center for Cancer Research, and Department of Radiation Oncology at Massachusetts General Hospital, Harvard Medical School (https://www.whwanglab.org/) is looking for an exceptional associate computational biologist (ACB) who wants to work as an integral part of a fun, collegial team on solving big problems in spatial and systems oncology and with a principal investigator who prioritizes mentorship. Prior ACBs have been co-first authors and co-authors on multiple high impact papers each and presented as lead authors at conferences. This training experience is ideal for preparing candidates who are interested in pursuing subsequent PhD and/or MD training.
You will have an opportunity to work closely with Dr. Hwang and other team members to better understand the multicellular communities and intercellular interactions involved in conferring therapeutic resistance in cancer. You will develop and apply computational methods in single-cell and spatial biology to patient tumors. The Hwang Lab works broadly on gastrointestinal malignancies with a particular focus on pancreatic cancer.
Ideal candidates should have a strong interest in computational genomics and oncology, prior experience in computational biology and/or machine learning research, be motivated and willing to learn new techniques, thrive in both collaborative and independent situations, and be highly organized. This position has a 2-year minimum commitment. In addition to playing a supporting role in various projects across the team, the candidate will have the opportunity to lead or co-lead an independent project during their tenure.
Responsibilities:
The ACB will develop computational models and perform data analyses to support the diverse research efforts in the laboratory. You will become familiar with shell scripting and programming in Python (ScanPy, NumPy, pandas, Matplotlib, Seaborn, scikit-learn) and R (tidyr, ggplot2, dplyr, lme4).
Requirements:
A Bachelor’s degree is required before the anticipated start date, with prior research/coursework experience in computational biology. This position is full time. To apply, please send your resume, short summary of prior academic/research experiences and career goals, and a list of personal/professional references to William Hwang, MD, PhD at whwang1@mgh.harvard.edu.
Additional information: https://csb.mgh.harvard.edu/information/careers#post_135
Massachusetts General Hospital and Harvard Medical School uphold a commitment to affirmative action and equal opportunity.
Postdoctoral Fellow Job Description
We are seeking an outstanding postdoctoral fellow interested in cancer biology/neuroscience. We seek applications from candidates with a PhD, MD, or MD-PhD degrees who are US residents. Experimental, computational, and hybrid experimental-computational candidates are all encouraged to apply.
Research in the Hwang Laboratory is focused on studying tumor-stroma interactions in gastrointestinal malignancies at unprecedented resolution through the development and application of techniques in single-cell and spatial biology, multiplexed imaging, and functional genetic screens to patient-derived specimens, organoids, and mouse models to elucidate mechanisms of:
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Therapeutic resistance mediated by genetic, epigenetic, and phenotypic factors including cell state plasticity
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Treatment-mediated remodeling of the spatial microarchitecture of tumors and underlying cancer cell-stromal interactions
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Tumor-nerve crosstalk, which plays a critical role in the pathophysiology and morbidity of many malignancies but remains understudied.
The postdoctoral fellow will closely with Dr. Hwang, who prioritizes mentorship and career development for trainees. The Hwang lab is interested in developing highly translatable biomarkers to track tumor remodeling and guide adaptive therapeutic approaches, including integration of liquid and tissue biopsies with the goal of unlocking latent in situ information from less morbid and more convenient liquid biopsies.
Interested candidates are invited to submit application materials consisting of:
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Cover letter indicating research background/interests/plan including a statement of impact
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Curriculum vitae
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Three references
Please send applications to Serena Sullivan (sullivan.serena@mgh.harvard.edu) and Dr. Hwang (whwang1@mgh.harvard.edu).
Additional information: https://csb.mgh.harvard.edu/information/careers.
Massachusetts General Hospital and Harvard Medical School uphold a commitment to affirmative action and equal opportunity.
Research Technician Job Posting
Description:
We are looking for an exceptional research technician who wants to work as an integral part of a fun, collegial team on solving big problems in spatial and systems oncology and with a principal investigator who prioritizes mentorship. Prior technicians have been co-first authors and co-authors on 3 or more high impact papers each, presented as lead authors at conferences, and gained admission to prestigious MD and PhD programs such as the Harvard-MIT Health Sciences and Technology program. This training experience is ideal for preparing candidates who are interested in pursuing subsequent PhD and/or MD training.
The research technician will have an opportunity to work closely with Dr. Hwang and team members to elucidate mechanisms of therapeutic resistance in cancer, develop translatable biomarkers to track tumor remodeling during treatment, and/or investigate the interface of cancer with the nervous system. You will have the opportunity to develop and apply techniques in single-cell and spatial biology, imaging, genetic screens, and neuroscience to patient tumors and cutting-edge model systems of cancer (e.g., organoids, mouse models). The Hwang Lab works broadly on gastrointestinal malignancies with a particular focus on pancreatic cancer.
Ideal candidates should have a strong interest in cancer biology and/or neuroscience, prior experience in laboratory biological research, motivated and willing to learn new techniques, thrive in both collaborative and independent situations, and highly organized. This position has a 2-year minimum commitment and if the candidate is interested, they may have the opportunity to lead or co-lead an independent project during their tenure.
Responsibilities:
The research technician will design and execute experimental protocols in support of the diverse research efforts in the laboratory. Specific responsibilities and skills that will be developed through this role include but are not limited to leading edge spatial proteotranscriptomics, multiplexed confocal/immunofluorescence imaging, single-cell and -nucleus RNA-sequencing and multiomics, blood/plasma multiomics, advanced 2D and 3D cell culture techniques, molecular cloning/lentiviral transduction/CRISPR genetic engineering, mouse colony management, survival surgeries and orthotopic pancreatic transplants, dorsal root ganglion dissections and neuronal culture techniques, live cell imaging and neurite tracking, immunohistochemistry, Western blot, qPCR, drug screens, and flow cytometry.
Requirements:
A Bachelor’s degree is required before the anticipated start date, with prior laboratory experience in laboratory cancer biology and/or neuroscience preferred. This position is full time. To apply, please send your resume, short summary of prior academic/research experiences and career goals, and a list of personal/professional references to Dr. Hwang (whwang1@mgh.harvard.edu).
Additional information: https://csb.mgh.harvard.edu/information/careers#post_136
Massachusetts General Hospital and Harvard Medical School uphold a commitment to affirmative action and equal opportunity