DIVERSITY STATEMENT
The Hwang Lab strongly believes that the most effective team is one composed of diverse backgrounds, skills, interests and perspectives. We are therefore committed to fostering a diverse scientific community and welcome all individuals irrespective of gender, race/ethnicity, sexual orientation, religion, cultural background, socioeconomic status, or physical ability. We are dedicated to understanding and challenging our own unconscious biases, as well as educating ourselves regarding the challenges that others may face in order to nurture an inclusive workplace that is welcoming for all.
Associate Computational Biologist
Description:
This training experience is ideal for preparing candidates who are interested in pursuing subsequent PhD and/or MD training. Ideal candidates should have a strong interest in computational genomics and oncology, prior experience in computational biology and/or machine learning research, be motivated and willing to learn new techniques, thrive in both collaborative and independent situations, and be highly organized. Prior ACBs have been co-first authors and co-authors on multiple high impact papers each and presented as lead authors at conferences. This position has a 2-year minimum commitment.
Responsibilities:
The ACB will develop computational models and perform data analyses to support the diverse research efforts in the laboratory. You will become familiar with shell scripting and programming in Python (ScanPy, NumPy, pandas, Matplotlib, Seaborn, scikit-learn) and R (tidyr, ggplot2, dplyr, lme4).
Requirements:
A Bachelor’s degree is required before the anticipated start date, with prior research/coursework experience in computational biology.
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We are not currently hiring at this time. However, please feel free to email Dr. Hwang at <whwang1@mgh.harvard.edu> if you would like to connect.​
Postdoctoral Fellow
The postdoctoral fellow will work closely with Dr. Hwang, who prioritizes mentorship and career development for trainees. Research in the Hwang Laboratory is focused on studying tumor-stroma interactions in gastrointestinal malignancies at unprecedented resolution through the development and application of techniques in single-cell and spatial biology, multiplexed imaging, and functional genetic screens to patient-derived specimens, organoids, and mouse models to elucidate mechanisms of:
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Therapeutic resistance mediated by genetic, epigenetic, and phenotypic factors including cell state plasticity
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Treatment-mediated remodeling of the spatial microarchitecture of tumors and underlying cancer cell-stromal interactions
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Tumor-nerve crosstalk, which plays a critical role in the pathophysiology and morbidity of many malignancies but remains understudied.
Postdoctoral fellow applications require the following materials:
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Cover letter indicating research background/interests/plan including a statement of impact
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Curriculum vitae
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Three references
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We are not currently hiring at this time. However, please feel free to email Dr. Hwang at <whwang1@mgh.harvard.edu> if you would like to connect.​​
Research Technician
Description:
This training experience is ideal for preparing candidates who are interested in pursuing subsequent PhD and/or MD training. Prior technicians have been co-first authors and co-authors on 3 or more high impact papers each, presented as lead authors at conferences, and gained admission to prestigious MD and PhD programs such as the Harvard-MIT Health Sciences and Technology program. Ideal candidates should have a strong interest in cancer biology and/or neuroscience, prior experience in laboratory biological research, motivated and willing to learn new techniques, thrive in both collaborative and independent situations, and highly organized. This position has a 2-year minimum commitment.
Responsibilities:
The research technician will design and execute experimental protocols in support of the diverse research efforts in the laboratory. Specific responsibilities and skills that will be developed through this role include but are not limited to leading edge spatial proteotranscriptomics, multiplexed confocal/immunofluorescence imaging, single-cell and -nucleus RNA-sequencing and multiomics, blood/plasma multiomics, advanced 2D and 3D cell culture techniques, molecular cloning/lentiviral transduction/CRISPR genetic engineering, mouse colony management, survival surgeries and orthotopic pancreatic transplants, dorsal root ganglion dissections and neuronal culture techniques, live cell imaging and neurite tracking, immunohistochemistry, Western blot, qPCR, drug screens, and flow cytometry.
Requirements:
A Bachelor’s degree is required before the anticipated start date, with prior laboratory experience in laboratory cancer biology and/or neuroscience preferred.
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We are not currently hiring at this time. However, please feel free to email Dr. Hwang at <whwang1@mgh.harvard.edu> if you would like to connect.​