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PUBLICATIONS AND PATENTS

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Guo JA,** Hoffman HI,** Shroff S, Chen P, Hwang PG, Kim DY, Kim DW, Cheng SW, Zhao D, Mahal BA, Alshalafa M, Niemierko A, Wo JY, Loeffler JS, Fernandez-del Castillo C, Jacks T, Aguirre AJ, Hong TS, Mino-Kenudson M, Hwang WL. Pan-cancer transcriptomic predictors of perineural invasion improve occult histopathological detection. Clinical Cancer Research. 2021;27(10):2807-2815. This article was featured on the cover of the May 15, 2021 issue of Clinical Cancer Research. 

 

Hwang WL,# Jagadeesh KA,# Guo JA#, Hoffman HI#, Yadollahpour P, Reeves J, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi S, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco M, Nguyen L, Delorey T, Phillips D, Barth JL, Kern M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgii V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem J, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Fernandez-del Castillo C, Liss AS, Ting DT, Jacks T, Regev A. Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nature Genetics. 2022;54(8):1178-1191. This article was featured on the cover of the August 2022 issue of Nature Genetics. 

 

Research Investigations
  1. Chen SY, Kung HC, Espinoza B, Washington I, Chen K, Wang J, Zlomke H, Loycano MA, Wang R, Pickup M, Burns Iii WR, Fu J, Hwang WL‡, Zheng L‡. (2024). Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGFβ depletion. JCI Insight, e182766. doi: 10.1172/jci.insight.182766. Online ahead of print.

  2. Shiau C†*, Cao J†, Gong D*, Gregory MT, Caldwell NJ, Yin X*, Cho JW, Wang PL*, Su J*, Wang S*, Reeves JW, Kim TK, Kim Y, Guo JA*, Lester NA*, Bae JW*, Zhao R, Schurman N, Barth JL, Ganci ML, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Fernandez-del Castillo C, Mino-Kenudson M, Ting DT, Hemberg M‡, Hwang WL‡. (2024). Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment. Nature Genetics. doi: 10.1038/s41588-024-01890-9. Online ahead of print.

  3. Cephas AT, Hwang WL, Maitra A, Parnas O, DelGiorno KE. (2023). It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease. Gut, 72(6), 1211–1219. doi: 10.1136/gutjnl-2022-329313. 

  4. Bianchi A, De Castro Silva I, Deshpande NU, Singh S, Mehra S, Garrido VT, Guo X, Nivelo LA, Kolonias DS, Saigh SJ, Wieder E, Rafie CI, Dosch AR, Zhou Z, Umland O, Amirian H, Ogobuiro IC, Zhang J, Ban Y, Shiau C*, Nagathihalli NS, Montgomery EA, Hwang WL, Brambilla R, Komanduri K, Villarino AV, Toska E, Stanger BZ, Gabrilovich DI, Merchant NB, Datta J. (2023). Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer. Cancer Discovery, 13(6), 1428–1453. doi: 10.1158/2159-8290.CD-22-1046.

  5. Shiau C*, Su J*, Guo JA*, Hong TS, Wo JY, Jagadeesh KA‡, Hwang WL‡. (2022). Treatment-associated remodeling of the pancreatic cancer endothelium at single-cell resolution. Frontiers in Oncology, 12, 929950. doi: 10.3389/fonc.2022.929950

  6. Seldon CS, Meiyappan K, Hoffman H*, Guo JA*, Goel N, Hwang WL, Nguyen PL, Mahal BA, Alshalalfa M. (2022). Genomic alternations predictive of poor clinical outcomes in pan-cancer. Oncotarget, 13, 1069–1077. doi: 10.18632/oncotarget.28276.

  7. Hwang WL†, Jagadeesh KA†, Guo JA†*, Hoffman HI†*, Yadollahpour P, Reeves J, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi S, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J*, Shiau C*, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco M, Nguyen L, Delorey T, Phillips D, Barth JL, Kern M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgii V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem J, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Fernandez-del Castillo C, Liss AS, Ting DT, Jacks T, Regev A. (2022). Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nature Genetics, 54(8), 1178–1191. doi: 10.1038/s41588-022-01134-8.

    • This article was featured on the cover of the August 2022 issue of Nature Genetics.

  8. Guo JA*, Alshalalfa M, Kim DY, Hoffman HI*, Shiau C*, Su J*, Hwang WL‡, Mahal BA‡. (2022). DNA repair and immune checkpoint blockade response. Cancer Genetics, 264-265, 1–4. doi: 10.1016/j.cancergen.2022.02.007.

  9. Swami N, Hwang WL, Guo JA*, Hoffman H*, Abramowitz MC, Elbakouny Z, Beltran H, Chipidza F, Choueiri T, Dal Pra A, Huang F, Kaochar S, Kantoff P, Kim DW, Kishan AU, Kobetz E, Marinac C, Mucci LA, Muralidhar V, Pollack A, Sanford NN, Schaeffer EM, Spratt DE, Zhao SG, Rebbeck TR, Nguyen PL, Feng FY, Mahal BA, Alshalalfa M. (2021). Novel genomic signature predictive of response to immune checkpoint blockade: a pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE). Cancer Genetics, 258-259, 61–68. doi: 10.1016/j.cancergen.2021.08.004.

  10. Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan S-L, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ME, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T. (2021). Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes. Immunity, 54(10), 2338–2353.e6. doi: 10.1016/j.immuni.2021.08.026.

  11. Burger ML, Cruz AM, Crossland GE, Gaglia G, Ritch CC, Blatt SE, Bhutkar A, Canner D, Kienka T, Tavana S, Garmilla A, Schenkel JM, Hillman M, de los Rios Kobara I, Li A, Hwang WL, Westcott PMK, Regev A, Santagata S, Jacks T. (2021). Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors. Cell, 184(19), 4996–5014.e26. doi: 10.1016/j.cell.2021.08.020.

  12. Freed-Pastor WA, Lambert LJ, Ely ZA, Pattada NB, Bhutkar A, Eng G, Mercer KL, Garcia AP, Lin L, Rideout WM III, Hwang WL, Schenkel JM, Jaeger AM, Bronson RT, Westcott PMK, Hether T, Divakar P, Reeves JW, Deshpande V, Delorey T, Phillips D, Yilmaz OH, Regev A, Jacks T. (2021). The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer. Cancer Cell, 39(10), 1342–1360.e14. doi: 10.1016/j.ccell.2021.07.007.

  13. Guo JA†*, Hoffman HI†*, Shroff S, Chen P, Hwang PG, Kim DY, Kim DW, Cheng SW, Zhao D, Mahal BA, Alshalafa M, Niemierko A, Wo JY, Loeffler JS, Fernandez-del Castillo C, Jacks T, Aguirre AJ, Hong TS, Mino-Kenudson M, Hwang WL‡. (2021). Pan-cancer transcriptomic predictors of perineural invasion improve occult histopathological detection. Clinical Cancer Research, 27(10), 2807–2815. doi: 10.1158/1078-0432.CCR-20-4382.

    • This article was featured on the cover of the May 15, 2021 issue of Clinical Cancer Research

  14. Lebow ES, Hwang WL, Zieminski S, Wang Y, Niemierko A, Mehan WA, Oh K, Khandekar M, Willers H, Shih HA. (2020). Early experience with hippocampal avoidance whole brain radiation therapy and simultaneous integrated boost for brain metastases. Journal of Neuro-Oncology, 148(1), 81–88. doi: 10.1007/s11060-020-03491-y.

  15. Kim DW, Buzurovic IM, Mahal BV, Hwang WL, Oladeru OT, O’Farrell DA, Harris TC, Margalit DN, Lam M, Devlin PM. (2020). Combined interstitial and surface high-dose-rate brachytherapy treatment of squamous cell carcinoma of the hand. Journal of Contemporary Brachytherapy, 12(1), 48–52. doi: 10.5114/jcb.2020.92408.

  16. Pike LRG, Royce TJ, Mahal AR, Kim DW, Hwang WL, Mahal BA, Sanford NN. (2020). Outcomes of HPV-associated squamous cell carcinoma of the head and neck: impact of race and socioeconomic status. Journal of the National Comprehensive Cancer Network, 18(2), 177–184. doi: 10.6004/jnccn.2019.7356.

  17. Lamba N, Hwang WL, Kim DW, Niemierko A, Marciscano AE, Mehan WA Jr, Benayoun MD, Curry WT, Barker FG 2nd, Martuza RL, Dunn IF, Claus E, Bi WL, Aizer AA, Alexander BM, Oh KS, Loeffler JS, Shih HA. (2020). Atypical histopathological features and the risk of treatment failure in non-malignant meningiomas: a multi-institutional analysis. World Neurosurgery, 133, e804–e812. doi: 10.1016/j.wneu.2019.10.002.

  18. Niyazi M, Niemierko A, Paganetti H, Sohn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA. (2020). Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model. Radiotherapy and Oncology, 142, 154–161. doi: 10.1016/j.radonc.2019.09.008.

  19. Sanford NN, Hwang WL, Pike LRG, Lam AC, Royce TJ, Mahal BA. (2019). Trimodality therapy for HPV-positive oropharyngeal cancer: a population-based study. Oral Oncology, 98, 28–34. doi: 10.1016/j.oraloncology.2019.09.009.

  20. Liu KX, Lamba N, Hwang WL, Niemierko A, DuBois SG, Haas-Kogan DA. (2019). Risk stratification by somatic mutation burden in Ewing sarcoma. Cancer, 125(8), 1357–1364. doi: 10.1002/cncr.31919.

  21. Hwang WL, Wolfson RL, Niemierko A, Marcus KJ, DuBois S, Haas-Kogan D. (2019). Clinical impact of tumor mutational burden in neuroblastoma. Journal of the National Cancer Institute, 111(7), 695–699. doi: 10.1093/jnci/djy157.

  22. Sanford NN, Mahal BA, Royce TJ, Pike LRG, Hwang WL.‡ (2019). Sex disparity and copy number alterations in esophageal squamous cell carcinoma. Clinical Gastroenterology and Hepatology, 17(6), 1207–1209. doi: 10.1016/j.cgh.2018.08.026.

  23. Pike LRG, Hwang WL, Royce TJ, Sanford NN, Mahal BA. (2018). HPV status predicts for improved survival following chemotherapy in metastatic squamous cell carcinoma of the oropharynx. Oral Oncology, 86, 69–74. doi: 10.1016/j.oraloncology.2018.09.007.

  24. Hwang WL, Tendulkar RD, Niemierko A, Agrawal S, Stephans KL, Spratt DE, Hearn JW, Koontz BF, Lee WR, Michalski JM, Pisansky TM, Liauw SL, Abramowitz MC, Pollack A, Moghanaki D, Anscher MS, Den RB, Zietman AL, Stephenson AJ, Efstathiou JA. (2018). Comparison Between Adjuvant and Early-Salvage Postprostatectomy Radiotherapy for Prostate Cancer With Adverse Pathological Features. JAMA Oncology, 4(5), e175230. doi: 10.1001/jamaoncol.2017.5230.

  25. Hwang WL, Niemierko A, Hwang KL, Hubbeling H, Schapira E, Gainor JF, Keane FK. (2018). Clinical Outcomes in Patients With Metastatic Lung Cancer Treated With PD-1/PD-L1 Inhibitors and Thoracic Radiotherapy. JAMA Oncology, 4(2), 253–255. doi: 10.1001/jamaoncol.2017.3808.

  26. Kim D, Niemierko A, Hwang WL, Stemmer-Rachamimov AO, Curry WT, Barker FG II, Martuza RL, Oh KS, Loeffler JS, Shih HA. (2018). Histopathological prognostic factors of recurrence following surgery and radiation therapy for atypical and malignant meningiomas. Journal of Neurosurgery, 128(4), 1123–1132. doi: 10.3171/2016.11.JNS16913.

  27. Harada BT, Hwang WL, Deindl S, Zhuang X. (2016). Stepwise nucleosome translocation by RSC remodeling complexes. eLife, 5, e10051. doi: 10.7554/eLife.10051.

  28. Hwang WL, Marciscano AE, Niemierko A, Kim D, Stemmer-Rachamimov AO, Curry WT, Barker FG II, Shih HA, Larvie M. (2016). Imaging and extent of surgical resection predict risk of meningioma recurrence better than WHO histopathological grade. Neuro-Oncology, 18(6), 863–872. doi: 10.1093/neuonc/nov285.

  29. Hwang WL†, Deindl S†, Harada BT, Zhuang X. (2014). Histone H4 tail mediates allosteric regulation of nucleosome remodeling by linker DNA. Nature, 512(7513), 213–217. doi: 10.1038/nature13380.

    • ​Previews. Singh HR, Ladurner AG. ACF takes the driver’s seat. Molecular Cell. 2014;55(3):345-6. 

  30. Deindl S, Hwang WL, Hota SK, Blosser TR, Prasad P, Bartholomew B, Zhuang X. (2013). ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps. Cell, 152(3), 442–452. doi: 10.1016/j.cell.2012.12.040.

  31. Maglia G, Heron AJ, Hwang WL, Holden MA, Mikhailova E, Li Q, Cheley S, Bayley H. (2009). Droplet networks with incorporated protein diodes show collective properties. Nature Nanotechnology, 4(7), 437–440. doi: 10.1038/nnano.2009.121.

    • News & Views. Aguilella VM, Alcaraz A. A fluid approach to simple circuits. Nature Nanotechnology. 2009;4(7):403-4. 

  32. Hwang WL, Chen M, Cronin B, Holden MA, Bayley H. (2008). Asymmetric droplet interface bilayers. Journal of the American Chemical Society, 130(18), 5878–5879. doi: 10.1021/ja802089s.

  33. Syeda R, Holden MA, Hwang WL, Bayley H. (2008). Rapid screening of blockers against a potassium channel with a droplet interface bilayer array. Journal of the American Chemical Society, 130(46), 15543–15548. doi: 10.1021/ja804968g.

  34. Hwang WL, Holden MA, White S, Bayley H. (2007). Electrical behavior of droplet interface bilayer networks: experimental analysis and modeling. Journal of the American Chemical Society, 129(38), 11854–11864. doi: 10.1021/ja074071a.

    • Featured in Stix G. A simple mimic: water droplets encased in fat simulate cell membranes. Scientific American. 2007;297(5):12-3. 

  35. Xu T, Hwang WL, Su F, Chakrabarty K. (2007). Automated design of pin-constrained digital microfluidic biochips under droplet-interference constraints. Journal on Emerging Technologies in Computing Systems, 3(3), 14. doi: 10.1145/1295231.1295235.

  36. Su F, Hwang WL, Mukherjee A, Chakrabarty K. (2007). Testing and diagnosis of realistic defects in digital microfluidic biochips. Journal of Electronic Testing, 23, 219-233. doi: 10.1007/s10836-006-0554-8.

  37. Curry A, Hwang WL, Wax A. (2006). Epi-illumination through the microscope objective applied to darkfield imaging and microspectroscopy of nanoparticle interaction with cells in culture. Optics Express, 14(14), 6535–6542. doi: 10.1364/oe.14.006535.

  38. Szu H, Hwang WL. Self-supervised backpropagation in stem cells. (2003). IEEE Connections, 1(3), 8-9.

Other Peer-Reviewed Scholarship
  1. Shi DD†*, Guo JA†*, Hoffman HI*, Su J, Mino-Kenudson M, Barth JL, Schenkel JM, Loeffler JS, Shih HA, Hong TS, Wo JY, Aguirre AJ, Jacks TJ, Zheng L, Wen PY, Wang TC, Hwang WL. (2022). Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities. Lancet Oncology, 23(2), e62–e74. doi: 10.1016/S1470-2045(21)00596-9.

  2. Guo JA†*, Hoffman HI†*, Weekes CD, Zheng LZ, Ting DT, Hwang WL. (2021). Refining the molecular framework for pancreatic cancer with single-cell and spatial technologies. Clinical Cancer Research, 27(14), 3825–3833. doi: 10.1158/1078-0432.CCR-20-4712.

  3. Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta AM, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR. (2020). Multidisciplinary standards of care and recent progress in pancreatic exocrine cancers. CA: A Cancer Journal for Clinicians, 70(5), 375–403. doi: 10.3322/caac.21626.

  4. Mehta A, Hwang WL, Weekes C. (2020). The present and future of systemic and microenvironment-targeted therapy for pancreatic adenocarcinoma. Annals of Pancreatic Cancer, 3, 3. doi: 10.21037/apc-2020-pda-05.

  5. Hwang WL†, Pike LRG†, Royce TJ, Mahal BA, Loeffler JS. (2018). Safety of combining radiotherapy with immune checkpoint inhibitors. Nature Reviews Clinical Oncology, 15(8), 477–494. doi: 10.1038/s41571-018-0046-7.

  6. Hwang WL, Pleskow HM, Miyamoto DT. (2018). Molecular analysis of circulating tumor cells: biomarkers beyond enumeration. Advanced Drug Delivery Reviews, 125, 122–131. doi: 10.1016/j.addr.2018.01.003.

  7. Hwang KL, Hwang WL, Bussière MR, Shih HA. (2017). The role of radiotherapy in the management of high-grade meningiomas. Chinese Clinical Oncology, 6(Suppl 1), S5. doi: 10.21037/cco.2017.06.09.

  8. Hwang WL, Hwang KL, Miyamoto DT. (2016). The promise of circulating tumor cells for precision cancer therapy. Biomarkers in Medicine, 10(12), 1269–1285. doi: 10.2217/bmm-2016-0192.

  9. Bayley H, Cronin B, Heron A, Holden MA, Hwang WL, Syeda R, Thompson J, Wallace M. (2008). Droplet interface bilayers. Molecular BioSystems, 4(12), 1191–1208. doi: 10.1039/b808893d.

Preprints
  1. Shiau C†*, Cao J†, Gregory MT, Gong D*, Yin X*, Cho JW, Wang PL†, Su J†, Wang S†, Reeves JW, Kim TK, Kim Y, Guo JA†, Lester NA†, Schurman N, Barth JL. Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Fernandez-del Castillo C, Mino-Kenudson M, Ting DT, Hemberg M‡, Hwang WL‡. (2023). Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis. bioRxiv. doi: 10.1101/2023.06.28.546848

  2. Hwang WL†, Jagadeesh KA†, Guo JA†*, Hoffman HI†*, Yadollahpour P, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi S, Schapiro D, Reeves J, Zollinger DR,  Eng G, Schenkel JM, Freed-Pastor WA, Rodrigues C, Gould J, Lambden C, Porter C, Tsankov A, Dionne D, Abbondanza D, Waldman J, Cuoco M, Nguyen L, Delorey T, Phillips D, Ciprani D, Kern M, Mehta A, Fuhrman K, Fropf R, Beechem J, Loeffler JS, Ryan DP, Weekes CD, Ting DT, Ferrone CR, Wo JY, Hong TS, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Fernandez-del Castillo C, Liss AS, Jacks TE, Regev A. (2020). Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment. Preprint posted to bioRxiv. doi: 10.1101/2020.08.25.267336.

Reviews, chapters, monographs and editorials
  1. Wang PL*, Lester NA*, Guo JA*, Su J*, Shiau C*, Hwang WL. Chapter in Amit M, Scheff NN, editors. Cancer Neuroscience. Switzerland: Springer Nature; 2023. 205 p.

  2. Hoffman HI*, Guo JA*, Hwang WL. Drug discovery. Chapter in Eltorai A, Bakal JA, Wazer D, Kim D, editors. Translational Radiation Oncology. San Diego (CA): Elsevier. 2023. 736 p.

  3. Hoffman HI*, Guo JA*, Hawkins M, Bridgewater J, Wo JY, Hong TS, Hwang WL. Silver linings—an opportunity to improve clinical paradigms following the COVID-19 pandemic. JCO Oncology Practice. 2020;16(9): 532-4. 

  4. Hwang WL, Pammal S. What works in educational curricula. 2013;299-316. Chapter in Vasan N, Przybylo J, editors. Do Good Well: Your Guide to Leadership, Action, and Social Innovation. San Francisco (CA): Jossey-Bass; 2013. 558 p. 

  5. Su F, Hwang WL, Mukherjee A, Chakrabarty K. Testing and diagnosis of realistic defects in digital microfluidic biochips. 2008;287-312. Chapter in Tehranipoor M, editor. Emerging Nanotechnologies: Test, Defect Tolerance, and Reliability. New York (NY): Springer; 2008. 408 p. 

  6. Szu H, Chanyagorn P, Hwang WL, Paulin M, Yamakawa T. Collective and distributive swarm intelligence: evolutional biological survey. 2004;46-49. Chapter in Nakagawa H, Ishii K, Miyamoto H, editors. Brain-Inspired IT I. Hibikino, Kitakuyushu, Japan: Elsevier; 2004. 250 p. 

Letters to the Editor
  1. Hwang WL, Niemierko A, Efstathiou JA. Comparing adjuvant vs early-salvage radiotherapy after radical prostatectomy – reply. JAMA Oncology. 2018;4(11):1620-1. 

Legend

† = Co-first authorship

* = Mentee/trainee

‡ = Co-senior authorship

Patents

Pancreatic ductal adenocarcinoma signatures and uses thereof 

U.S. Provisional Application No. 63/069,035 

Filed: August 22, 2020 

Inventors: Aviv Regev, William Hwang, Karthik Jagadeesh, Jimmy Guo, Tyler Jacks

Treatment and detection of cancers having a neural-like progenitor, squamoid/basaloid-mesenchymal, or classical phenotype 

U.S. Provisional Application No. 63/346,670 

Filed: May 27, 2022 

Inventors: William Hwang, Jimmy Guo, Andrew Aguirre, Tyler Jacks, Jennifer Su, Carina Shiau 

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